Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002523)
Formula
SVG example
Hydrolysis
Reactant Capecitabine Product 5'-DFCR
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010335 Galocitabine 5'-DFCR Unclear - Unclear Galocitabine [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002521 5'-DFCR 5'-DFUR Unclear Capecitabine [2], [3]
MR010336 5'-DFCR 5'-DFUR Unclear - Unclear Galocitabine [4]
References
1 Simultaneous determination of a new anticancer drug galocitabine and its metabolites in blood by high-performance liquid chromatography
2 EUCRISA? (crisaborole) ointment, 2%, for topical use
3 A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma
4 Modified high-performance liquid chromatographic method for analysis of drotaverine in human plasma

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