Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013677)
Formula
SVG example
7-hydroxylation
Reactant Deoxycholic acid Product CA
Reactant Info Product Info
Metabolic Type Oxidation - 7-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013675 Deoxycholic acid 12-keto-DCA Oxidation - 12-OH-dehydrogenation Deoxycholic acid [1]
MR013670 Deoxycholic acid 15beta-hydroxy-DCA Oxidation - 15-hydroxylation Deoxycholic acid [1]
MR013673 Deoxycholic acid 1beta-OH-DCA Unclear Deoxycholic acid [2]
MR013674 Deoxycholic acid 3-keto-DCA Oxidation - 3-OH-dehydrogenation Deoxycholic acid [1]
MR013672 Deoxycholic acid Taurocholic acid Unclear Deoxycholic acid [3]
MR013676 Deoxycholic acid UCA Oxidation - 7-hydroxylation Deoxycholic acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002545 Chenodeoxycholic acid Cholic acid Unclear Chenodeoxycholic acid [4]
MR005331 Dehydrocholic acid Cholic acid Reduction - Reduction Dehydrocholic acid [5], [6]
MR006022 Oxolithocholic acid CA Unclear Oxolithocholic acid [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006023 CA 7-oxo-DCA Unclear Oxolithocholic acid [7]
References
1 Deoxycholic acid transformations catalyzed by selected filamentous fungi
2 CYP3A Specifically Catalyzes 1-Hydroxylation of Deoxycholic Acid: Characterization and Enzymatic Synthesis of a Potential Novel Urinary Biomarker for CYP3A Activity
3 Increased sulfation and decreased 7alpha-hydroxylation of deoxycholic acid in ethinyl estradiol-induced cholestasis in rats
4 Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1. Biol Chem. 2019 Apr 24;400(5):625-628.
5 Triketocholanoic (dehydrocholic) acid. Hepatic metabolism and effect on bile flow and biliary lipid secretion in man
6 Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens. Appl Microbiol Biotechnol. 2011 Apr;90(1):127-35.
7 Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18.

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