Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002577)
Formula Reactant Cabazitaxel Product Cabazitaxel metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002576 Cabazitaxel RPR112698 Oxidation - 7-O-Demethylation Cabazitaxel [1]
MR002575 Cabazitaxel RPR123142 Oxidation - 10-O-Demethylation Cabazitaxel [1]
MR002578 Cabazitaxel RPR130523 Unclear Cabazitaxel [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002573 Cabazitaxel metabolite M1 Cabazitaxel metabolite M2 Oxidation - Hydroxylation Cabazitaxel [1]
References
1 A phase I open-label study investigating the disposition of [14C]-cabazitaxel in patients with advanced solid tumors Anticancer Drugs. 2015 Mar;26(3):350-8. doi: 10.1097/CAD.0000000000000185.

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