Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002736)
Formula
SVG example
Hydroxylation
Reactant Etodolac Product 8-(1-hydroxyethyl)etodolac
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002738 Etodolac 4-ureido-etodolac Unclear Etodolac [1]
MR002735 Etodolac 6-hydroxyetodolac Oxidation - 6-Hydroxylation Etodolac [2]
MR002734 Etodolac 7-hydroxyetodolac Oxidation - 7-Hydroxylation Etodolac [2]
MR002737 Etodolac Etodolac acyl glucuronide Conjugation - Glucuronidation Etodolac [2]
References
1 Etodolac clinical pharmacokinetics
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development Curr Med Chem. 2009;16(27):3480-675. doi: 10.2174/092986709789057635.

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