Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002737)
Formula
UGT1A3 ...
SVG example
Glucuronidation
Reactant Etodolac Product Etodolac acyl glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002738 Etodolac 4-ureido-etodolac Unclear Etodolac [1]
MR002735 Etodolac 6-hydroxyetodolac Oxidation - 6-Hydroxylation Etodolac [2]
MR002734 Etodolac 7-hydroxyetodolac Oxidation - 7-Hydroxylation Etodolac [2]
MR002736 Etodolac 8-(1-hydroxyethyl)etodolac Oxidation - Hydroxylation Etodolac [1]
References
1 Etodolac clinical pharmacokinetics
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development Curr Med Chem. 2009;16(27):3480-675. doi: 10.2174/092986709789057635.

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