Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002909)
Formula
CYP2C19 ...
SVG example
Oxidation
Reactant TCBZ-SX Product Triclabendazole sulfone metabolite
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1B1 (CYP1B1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002908 Triclabendazole TCBZ-SX Oxidation - Oxidation Triclabendazole [1], [2]
References
1 Total determination of triclabendazole and its metabolites in bovine tissues using liquid chromatography-tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 1;1109:54-59. doi: 10.1016/j.jchromb.2019.01.021.
2 Egaten FDA label

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