Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002951)
Formula
ADA
SVG example
Demethylation
Reactant Nelarabine Product Arabinofuranosylguanine
Reactant Info Product Info
Metabolic Enzyme Adenosine aminohydrolase (ADA) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002950 Nelarabine Ara-G Other reaction - Phosphorylation Nelarabine [1], [2]
References
1 A new high-performance liquid chromatography method determines low production of 9-beta-D-arabinofuranosylguanine triphosphate, an active metabolite of nelarabine, in adult T-cell leukemia cells Oncol Rep. 2010 Feb;23(2):499-504.
2 Nelarabine Drugs. 2008;68(4):439-47. doi: 10.2165/00003495-200868040-00004.

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