Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002977)
Formula
SVG example
Unclear
Reactant Acetoacetyl-CoA Product HMG-CoA
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002976 Acetyl-CoA Acetoacetyl-CoA Oxidation - Beta Oxidation Acetyl-CoA [1], [2]
MR006973 Acetoacetate Acetoacetyl-CoA Unclear HSDB-41 [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002982 Acetoacetyl-CoA Malonyl-CoA Unclear - Unclear Acetyl-CoA [4], [5], [6]
MR006974 Acetoacetyl-CoA Acetyl coenzyme A Unclear HSDB-41 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002980 HMG-CoA Acetoacetate Unclear - Unclear Acetyl-CoA [4], [2], [7]
MR002978 HMG-CoA Mevalonate Unclear - Unclear Acetyl-CoA [4], [8]
References
1 U. S. FDA Label -Acetyl-CoA
2 Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders. Front Endocrinol (Lausanne). 2022 Oct 20;13:972890. doi: 10.3389/fendo.2022.972890.
3 The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14.
4 Compartmentalised acyl-CoA metabolism and roles in chromatin regulation Mol Metab. 2020 Aug;38:100941. doi: 10.1016/j.molmet.2020.01.005.
5 High throughput (13)C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux. Microb Cell Fact. 2023 Jun 29;22(1):117. doi: 10.1186/s12934-023-02123-0.
6 Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program. Cell Rep. 2023 May 30;42(5):112488. doi: 10.1016/j.celrep.2023.112488.
7 In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis-Technical Aspects and Model Interpretation. Metabolites. 2021 Apr 28;11(5):279. doi: 10.3390/metabo11050279.
8 Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis. Redox Biol. 2023 Jun 16;64:102771. doi: 10.1016/j.redox.2023.102771.

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