Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002988)
Formula
CYP2C9 ...
SVG example
Unclear
Reactant Alitretinoin Product 4-oxo-9-cis-retinoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002986 Alitretinoin 13-cis-retinoic acid Unclear - Unclear Alitretinoin [1]
MR002991 Alitretinoin 4-hydroxy-9-cis-retinoic acid Unclear - Unclear Alitretinoin [2]
MR002989 Alitretinoin 4-oxo-13-cis-retinoic acid Unclear - Unclear Alitretinoin [1]
MR002990 Alitretinoin 4-oxo-all-trans-retinoic acid Unclear - Unclear Alitretinoin [1]
MR002987 Alitretinoin all-trans-retinoic acid Unclear - Unclear Alitretinoin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009635 9-cis RA 9-cis-4-Oxoretinoic acid Oxidation - Oxidation Tretinoin [3]
References
1 The single-dose pharmacokinetics of alitretinoin and its metabolites are not significantly altered in patients with cirrhosis Br J Dermatol. 2014 Feb;170(2):408-14. doi: 10.1111/bjd.12546.
2 DailyMed : Alitretinoin
3 Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids

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