Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002999)
Formula
SVG example
Unclear
Reactant Ergocalciferol Product 20(OH)D2
Reactant Info Product Info
Metabolic Enzyme Cholesterol desmolase (CYP11A1) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003004 Ergocalciferol 20-hydroxyvitamin D Oxidation - Hydroxylation Ergocalciferol [1]
MR003002 Ergocalciferol 24(R),25dihydroxyvitamin D Unclear - Unclear Ergocalciferol [1]
MR002997 Ergocalciferol 25-hydroxyvitamin D Unclear - Unclear Ergocalciferol [1], [2], [3]
MR003003 Ergocalciferol Beta-ergocalciferol Unclear - Unclear Ergocalciferol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003001 20(OH)D2 1,20(OH)2D2 Unclear - Unclear Ergocalciferol [4]
MR003000 20(OH)D2 17,20(OH)2D2 Unclear - Unclear Ergocalciferol [4]
References
1 Vitamin D: mechanisms of action and clinical applications. Endocrinol Metab Clin North Am. 2017 Dec;46(4):xvii-xviii.
2 Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56.
3 CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev. 2007 Nov;23(8):631-6.
4 The Metabolic Activation of Sofosbuvir Is Impaired in an Experimental Model of NAFLD. Biology (Basel). 2022 Apr 30;11(5):693. doi: 10.3390/biology11050693.

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