Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002997)
Formula
CYP2R1 ...
SVG example
Unclear
Reactant Ergocalciferol Product 25-hydroxyvitamin D
Reactant Info Product Info
Metabolic Enzyme Vitamin D 25-hydroxylase (CYP2R1) DME Info
Cytochrome P450 2J2 (CYP2J2) DME Info
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002999 Ergocalciferol 20(OH)D2 Unclear - Unclear Ergocalciferol [1]
MR003004 Ergocalciferol 20-hydroxyvitamin D Oxidation - Hydroxylation Ergocalciferol [2]
MR003002 Ergocalciferol 24(R),25dihydroxyvitamin D Unclear - Unclear Ergocalciferol [2]
MR003003 Ergocalciferol Beta-ergocalciferol Unclear - Unclear Ergocalciferol [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002998 25-hydroxyvitamin D Calcitro Unclear - Unclear Ergocalciferol [2]
References
1 The Metabolic Activation of Sofosbuvir Is Impaired in an Experimental Model of NAFLD. Biology (Basel). 2022 Apr 30;11(5):693. doi: 10.3390/biology11050693.
2 Vitamin D: mechanisms of action and clinical applications. Endocrinol Metab Clin North Am. 2017 Dec;46(4):xvii-xviii.

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