Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003002)
Formula
CYP24A1 ...
SVG example
Unclear
Reactant Ergocalciferol Product 24(R),25dihydroxyvitamin D
Reactant Info Product Info
Metabolic Enzyme Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info
Calcidiol 1-monooxygenase (CYP27B1) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002999 Ergocalciferol 20(OH)D2 Unclear - Unclear Ergocalciferol [1]
MR003004 Ergocalciferol 20-hydroxyvitamin D Oxidation - Hydroxylation Ergocalciferol [2]
MR002997 Ergocalciferol 25-hydroxyvitamin D Unclear - Unclear Ergocalciferol [2], [3], [4]
MR003003 Ergocalciferol Beta-ergocalciferol Unclear - Unclear Ergocalciferol [2]
References
1 The Metabolic Activation of Sofosbuvir Is Impaired in an Experimental Model of NAFLD. Biology (Basel). 2022 Apr 30;11(5):693. doi: 10.3390/biology11050693.
2 Vitamin D: mechanisms of action and clinical applications. Endocrinol Metab Clin North Am. 2017 Dec;46(4):xvii-xviii.
3 Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56.
4 CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev. 2007 Nov;23(8):631-6.

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