Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003111)
Formula Reactant Lesinurad Product Lesinurad metabolite M3b
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003108 Lesinurad Lesinurad metabolite M3 Oxidation - Hydroxylation Lesinurad [1]
MR003110 Lesinurad Lesinurad metabolite M3a Oxidation - Hydroxylation Lesinurad [1]
MR003107 Lesinurad Lesinurad metabolite M3c Oxidation - Oxidation Lesinurad [1]
MR003109 Lesinurad Lesinurad metabolite M6 Unclear Lesinurad [1]
References
1 Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers Drug Metab Dispos. 2019 Feb;47(2):104-113. doi: 10.1124/dmd.118.080549.

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