Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003108)
Formula
CYP2C9 ...
SVG example
Hydroxylation
Reactant Lesinurad Product Lesinurad metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003110 Lesinurad Lesinurad metabolite M3a Oxidation - Hydroxylation Lesinurad [1]
MR003111 Lesinurad Lesinurad metabolite M3b Oxidation - Hydroxylation Lesinurad [1]
MR003107 Lesinurad Lesinurad metabolite M3c Oxidation - Oxidation Lesinurad [1]
MR003109 Lesinurad Lesinurad metabolite M6 Unclear Lesinurad [1]
References
1 Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers Drug Metab Dispos. 2019 Feb;47(2):104-113. doi: 10.1124/dmd.118.080549.

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