Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003107)
Formula
SVG example
Oxidation
Reactant Lesinurad Product Lesinurad metabolite M3c
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003108 Lesinurad Lesinurad metabolite M3 Oxidation - Hydroxylation Lesinurad [1]
MR003110 Lesinurad Lesinurad metabolite M3a Oxidation - Hydroxylation Lesinurad [1]
MR003111 Lesinurad Lesinurad metabolite M3b Oxidation - Hydroxylation Lesinurad [1]
MR003109 Lesinurad Lesinurad metabolite M6 Unclear Lesinurad [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003106 Lesinurad metabolite M3c Lesinurad metabolite M4 Oxidation - N-Dealkylation Lesinurad [1]
References
1 Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers Drug Metab Dispos. 2019 Feb;47(2):104-113. doi: 10.1124/dmd.118.080549.

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