Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003206)
Formula
CYP3A4 ...
SVG example
Reactant Desisobutyrylciclesonide Product Ciclesonide metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003207 Ciclesonide Desisobutyrylciclesonide Hydrolysis - Hydrolysis Ciclesonide [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003204 Desisobutyrylciclesonide C21-Lipid conjugation Other reaction - Esterification Ciclesonide [5]
MR003205 Desisobutyrylciclesonide Ciclesonide metabolite M3 Unclear Ciclesonide [5]
References
1 Ciclesonide Drugs. 2004;64(5):511-9; discussion 520-1. doi: 10.2165/00003495-200464050-00005.
2 Deposition and metabolism of inhaled ciclesonide in the human lung Eur Respir J. 2010 Nov;36(5):1113-9. doi: 10.1183/09031936.00172309.
3 LC-HRMS/MS study of the prodrug ciclesonide and its active metabolite desisobutyryl-ciclesonide in plasma after an inhalative administration to horses for doping control purposes. Drug Test Anal. 2022 Feb;14(2):252-261. doi: 10.1002/dta.3174.
4 Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-m aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging. Int J Pharm. 2021 Feb 15;595:120241. doi: 10.1016/j.ijpharm.2021.120241.
5 In Vitro metabolism of ciclesonide in human lung and liver precision-cut tissue slices Biopharm Drug Dispos. 2006 May;27(4):197-207. doi: 10.1002/bdd.500.

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