Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003257)
Formula
SVG example
Reactant Fospropofol Product Formaldehyde
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003256 Fospropofol Formic acid Unclear Fospropofol [1]
MR003259 Fospropofol Phosphate Unclear Fospropofol [1]
MR003258 Fospropofol Propofol Unclear Fospropofol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004593 Darodipine Formaldehyde Oxidation - N-demethylation; O-demethylation Darodipine [2]
MR006665 Doxepin hydrochloride Formaldehyde Oxidation - N-demethylation Doxepin hydrochloride [3]
MR007845 Fospropofol disodium Formaldehyde Unclear - Unclear Fospropofol disodium [4]
MR004248 Methylamine Formaldehyde Oxidation - Deamination Methylamine [5]
MR000289 N-hydroxymethyl-aripiprazole Formaldehyde Hydrolysis - Hydrolysis Aripiprazole lauroxil [6], [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007846 Formaldehyde Formic acid Unclear - Unclear Fospropofol disodium [4]
References
1 DrugBank(Pharmacology-Metabolism)Fospropofol
2 Inhibition of hepatic microsomal drug metabolism in rats by five calcium antagonists
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
4 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
5 Methylamine: a new endogenous modulator of neuron firing?
6 Aripiprazole Lauroxil: Pharmacokinetic Profile of This Long-Acting Injectable Antipsychotic in Persons With Schizophrenia J Clin Psychopharmacol. 2017 Jun;37(3):289-295. doi: 10.1097/JCP.0000000000000691.
7 Biological conversion of?aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug Results Pharma Sci. 2014 May 2;4:19-25. doi: 10.1016/j.rinphs.2014.04.002.

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