Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR0753)
Drug Name
Fospropofol
Synonyms
Fospropofol; Fospropofol [INN]; LZ257RZP7K; SCHEMBL3821874; ZINC2519740; 258516-89-1; AC1MI4YI; ACM258516891; CHEBI:135193; CHEMBL1201766; DB06716; DEA No. 2138; DTXSID50870295; FT-0727559; GTPL7475; UNII-LZ257RZP7K; [2,6-di(propan-2-yl)phenoxy]methyl dihydrogen phosphate
Indication Neuropathic pain [ICD11: 8E43] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 288.28 Topological Polar Surface Area 76
Heavy Atom Count 19 Rotatable Bond Count 6
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
3038498
ChEBI ID
CHEBI:135193
CAS Number
258516-89-1
Formula
C13H21O5P
Canonical SMILES
CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)(O)O
InChI
1S/C13H21O5P/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16)
InChIKey
QVNNONOFASOXQV-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Formaldehyde DM001748
712
Unclear 1 [3]
Formic acid DM000198
284
Unclear 1 [3]
Phosphate DM003103
1061
Unclear 1 [3]
Propofol DM003080
4943
Unclear 1 [3]
4-hydroxymethylpyrazole DM002054
3015210
Unclear 2 [3]
4-hydroxypropofol DM002068
3014064
Oxidation - 4-Hydroxylation 2 [4]
Propofol glucuronide DM003013
71751823
Conjugation - Glucuronidation 2 [4]
4-hydroxymethylpyrazole DM002054
3015210
Oxidation - 4-Hydroxylation 3 [4]
4-Hydroxypropofol-O-sulphate DM003010
10446031
Other reaction - Sulfonation 3 [4]
4-hydroxymethylpyrazole DM002054
3015210
Conjugation - Glucuronidation 4 [4]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR003256 Fospropofol Formic acid Unclear Unclear [3]
MR003257 Fospropofol Formaldehyde Unclear Unclear [3]
MR003258 Fospropofol Propofol Unclear Unclear [3]
MR003259 Fospropofol Phosphate Unclear Unclear [3]
MR003260 Propofol 4-hydroxymethylpyrazole Unclear CYP2E1 [3]
MR003261 Propofol 4-hydroxypropofol Oxidation - 4-Hydroxylation CYP2C9 ... [4]
MR003262 Propofol Propofol glucuronide Conjugation - Glucuronidation UGT1A8 ... [4]
MR003253 4-hydroxypropofol 4-Quinol sulfate Other reaction - Sulfonation Unclear [4]
MR003255 Propofol glucuronide 4-hydroxymethylpyrazole Oxidation - 4-Hydroxylation Unclear [4]
MR003254 4-Quinol sulfate 4-hydroxymethylpyrazole Conjugation - Glucuronidation UGT1A8 ... [4]
⏷ Show the Full List of 10 MR(s)
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Alkaline phosphatase (ALPL) DME0079 Homo sapiens
PPBT_HUMAN
3.1.3.1
[2]
References
1 Fospropofol was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 A double-blind, randomized, multicenter, dose-ranging study to evaluate the safety and efficacy of fospropofol disodium as an intravenous sedative for colonoscopy in high-risk populations. Am J Ther. 2013 Mar-Apr;20(2):163-71.
3 DrugBank(Pharmacology-Metabolism)Fospropofol
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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