Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003271)
Formula
CYP3A4 ...
SVG example
8-Hydroxylation
Reactant Nevirapine Product 8-hydroxynevirapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - 8-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003269 Nevirapine 12-hydroxynevirapine Oxidation - Hydroxylation Nevirapine [1], [2], [3]
MR003270 Nevirapine 2-hydroxynevirapine Oxidation - 2-Hydroxylation Nevirapine [1], [2]
MR003272 Nevirapine 3-hydroxynevirapine Oxidation - 3-Hydroxylation Nevirapine [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003267 8-hydroxynevirapine 8-hydroxynevirapine glucuronide metabolite Conjugation - Glucuronidation Nevirapine [4]
References
1 Disposition and biotransformation of the antiretroviral drug nevirapine in humans Drug Metab Dispos. 1999 Aug;27(8):895-901.
2 Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions J Antimicrob Chemother. 2014 Feb;69(2):476-82. doi: 10.1093/jac/dkt359.
3 Sulfation of 12-hydroxy-nevirapine by human SULTs and the effects of genetic polymorphisms of SULT1A1 and SULT2A1. Biochem Pharmacol. 2022 Oct;204:115243. doi: 10.1016/j.bcp.2022.115243.
4 U. S. FDA Label -Nevirapine

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