Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003287)
Formula
SVG example
1'-Hydroxylation
Reactant Triazolam Product Alpha-HT
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - 1'-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003285 Triazolam 4-hydroxytriazolame Oxidation - 4-Hydroxylation Triazolam [1], [2]
MR003286 Triazolam Alpha,4-HT Unclear Triazolam [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003284 Alpha-HT Alpha,4-HT Unclear Triazolam [1], [2]
References
1 Triazolam disposition Clin Pharmacol Ther. 1981 Jan;29(1):81-93. doi: 10.1038/clpt.1981.14.
2 Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site. Drug Metab Dispos. 2001 Jan;29(1):70-5.

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