Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003285)
Formula
SVG example
4-Hydroxylation
Reactant Triazolam Product 4-hydroxytriazolame
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - 4-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003286 Triazolam Alpha,4-HT Unclear Triazolam [1], [2]
MR003287 Triazolam Alpha-HT Oxidation - 1'-Hydroxylation Triazolam [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003280 4-hydroxytriazolame HM-CTB Unclear Triazolam [1], [2]
MR003281 4-hydroxytriazolame M-CTB Unclear Triazolam [1], [2]
References
1 Triazolam disposition Clin Pharmacol Ther. 1981 Jan;29(1):81-93. doi: 10.1038/clpt.1981.14.
2 Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site. Drug Metab Dispos. 2001 Jan;29(1):70-5.

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