Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003306)
Formula
SVG example
Reactant Androstanedione Product 5alpha-dihydrotestosterone
Reactant Info Product Info
Metabolic Enzyme Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003307 BRN-2217626 Androstanedione Unclear BRN-2217626 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003305 Androstanedione Epiandrosterone Unclear BRN-2217626 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012850 Androstenedione 5alpha-dihydrotestosterone Unclear Androstenedione [2]
MR004907 Dihydrotestosterone undecanoate 5alpha-dihydrotestosterone Unclear Testosterone undecanoate [3]
MR004535 Testosterone 5alpha-dihydrotestosterone Unclear AC-12166 [4]
MR004894 Testosterone 5alpha-dihydrotestosterone Unclear Testosterone cypionate [5]
MR004901 Testosterone 5alpha-dihydrotestosterone Unclear Testosterone undecanoate [3]
MR009624 Testosterone 5alpha-dihydrotestosterone Unclear - Unclear Testosterone enanthate [6]
MR009028 Testosterone 5alpha-dihydrotestosterone Unclear - Unclear EPIANDROSTERONE [7]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004902 5alpha-dihydrotestosterone 3-alpha-androstanediol Unclear Testosterone undecanoate [8]
MR009625 5alpha-dihydrotestosterone 3-alpha-Androstanediol glucuronide Conjugation - Glucuronidation Testosterone enanthate [6]
MR004904 5alpha-dihydrotestosterone 3-beta-androstenediol Unclear Testosterone undecanoate [8]
MR004895 5alpha-dihydrotestosterone 3alpha-Androstanediol glucuronide Unclear Testosterone cypionate [9]
MR004536 5alpha-dihydrotestosterone Androstanediol Unclear AC-12166 [4]
MR009029 5alpha-dihydrotestosterone 5alpha-androstane-3beta,17beta-diol(3beta,17beta-AAD) Reduction - 17beta-hydroxysteroid oxido-reduction EPIANDROSTERONE [7]
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References
1 Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans Trends Endocrinol Metab. 2003 Dec;14(10):473-9. doi: 10.1016/j.tem.2003.10.005.
2 Androstenedione (a Natural Steroid and a Drug Supplement): A Comprehensive Review of Its Consumption, Metabolism, Health Effects, and Toxicity with Sex Differences
3 Importance of measuring testosterone in enzyme-inhibited plasma for oral testosterone undecanoate androgen replacement therapy clinical trials
4 Preliminary observations on steroid metabolism in isolated epithelum of guinea pig seminal vesicle
5 The history of synthetic testosterone
6 DrugBank(Pharmacology-Metabolism):Testosterone enanthate
7 Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports
8 Metabolism of dihydrotestosterone in human liver: importance of 3alpha- and 3beta-hydroxysteroid dehydrogenase
9 DrugBank(Pharmacology-Metabolism):Testosterone cypionate

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