Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004901)
Formula
SVG example
Reactant Testosterone Product 5alpha-dihydrotestosterone
Reactant Info Product Info
Metabolic Enzyme Steroid 5-alpha-reductase 2 (SRD5A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003148 Testosterone Estradiol-17 beta Unclear Dehydroepiandrosterone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012850 Androstenedione 5alpha-dihydrotestosterone Unclear Androstenedione [2]
MR003306 Androstanedione 5alpha-dihydrotestosterone Unclear BRN-2217626 [3]
MR004907 Dihydrotestosterone undecanoate 5alpha-dihydrotestosterone Unclear Testosterone undecanoate [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004902 5alpha-dihydrotestosterone 3-alpha-androstanediol Unclear Testosterone undecanoate [5]
MR009625 5alpha-dihydrotestosterone 3-alpha-Androstanediol glucuronide Conjugation - Glucuronidation Testosterone enanthate [6]
MR004904 5alpha-dihydrotestosterone 3-beta-androstenediol Unclear Testosterone undecanoate [5]
MR004895 5alpha-dihydrotestosterone 3alpha-Androstanediol glucuronide Unclear Testosterone cypionate [7]
MR004536 5alpha-dihydrotestosterone Androstanediol Unclear AC-12166 [8]
MR009029 5alpha-dihydrotestosterone 5alpha-androstane-3beta,17beta-diol(3beta,17beta-AAD) Reduction - 17beta-hydroxysteroid oxido-reduction EPIANDROSTERONE [9]
⏷ Show the Full List of MR
References
1 Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742.
2 Androstenedione (a Natural Steroid and a Drug Supplement): A Comprehensive Review of Its Consumption, Metabolism, Health Effects, and Toxicity with Sex Differences
3 Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans Trends Endocrinol Metab. 2003 Dec;14(10):473-9. doi: 10.1016/j.tem.2003.10.005.
4 Importance of measuring testosterone in enzyme-inhibited plasma for oral testosterone undecanoate androgen replacement therapy clinical trials
5 Metabolism of dihydrotestosterone in human liver: importance of 3alpha- and 3beta-hydroxysteroid dehydrogenase
6 DrugBank(Pharmacology-Metabolism):Testosterone enanthate
7 DrugBank(Pharmacology-Metabolism):Testosterone cypionate
8 Preliminary observations on steroid metabolism in isolated epithelum of guinea pig seminal vesicle
9 Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports

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