Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003423)
Formula Reactant Tamsulosin Product Tamsulosin M-1 metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Deacetylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003427 Tamsulosin Tamsulosin AM-1 metabolite Oxidation - Oxidative Deamination Tamsulosin [1], [2]
MR003426 Tamsulosin Tamsulosin M-2 metabolite Oxidation - Hydroxylation Tamsulosin [1], [2]
MR003424 Tamsulosin Tamsulosin M-3 metabolite Oxidation - Hydroxylation Tamsulosin [1], [2]
MR003425 Tamsulosin Tamsulosin M-4 metabolite Oxidation - Demethylation Tamsulosin [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003418 Tamsulosin M-1 metabolite Tamsulosin M-1-Glu metabolite Conjugation - O-Glucuronidation Tamsulosin [2]
MR003417 Tamsulosin M-1 metabolite Tamsulosin M-1-Sul metabolite Conjugation - Sulfation Tamsulosin [2]
References
1 Pharmacokinetics and plasma protein binding of tamsulosin hydrochloride in rats, dogs, and humans Drug Metab Dispos. 1998 Mar;26(3):240-5.
2 Absorption, metabolism and excretion of tamsulosin hydrochloride in man Xenobiotica. 1996 Jun;26(6):637-45. doi: 10.3109/00498259609046739.

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