Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003455)
Formula Reactant Alectinib hydrochloride Product Alectinib metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003459 Alectinib metabolite M5 Alectinib metabolite M1a Oxidation - Oxidation Alectinib hydrochloride [1]
MR003458 Alectinib metabolite M5 Alectinib metabolite M1b Oxidation - Oxidation Alectinib hydrochloride [1]
MR003456 Alectinib metabolite M5 Alectinib metabolite M4 Oxidation - Oxidation Alectinib hydrochloride [1]
MR003460 Alectinib metabolite M5 Alectinib metabolite M6 Oxidation - N-dealkylation Alectinib hydrochloride [1]
References
1 In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes. Xenobiotica. 2018 Jun;48(6):546-554.

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