Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003459)
Formula Reactant Alectinib metabolite M5 Product Alectinib metabolite M1a
Reactant Info Product Info
Metabolic Enzyme Aldehyde dehydrogenase 1 (ALDH1) DME Info
Aldehyde dehydrogenase 2 (ALDH2) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003455 Alectinib hydrochloride Alectinib metabolite M5 Oxidation - Hydroxylation Alectinib hydrochloride [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003458 Alectinib metabolite M5 Alectinib metabolite M1b Oxidation - Oxidation Alectinib hydrochloride [1]
MR003456 Alectinib metabolite M5 Alectinib metabolite M4 Oxidation - Oxidation Alectinib hydrochloride [1]
MR003460 Alectinib metabolite M5 Alectinib metabolite M6 Oxidation - N-dealkylation Alectinib hydrochloride [1]
References
1 In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes. Xenobiotica. 2018 Jun;48(6):546-554.

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