Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003503)
Formula
SVG example
Reactant L-Tyrosine Product DOPA
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005861 L-tyrosine Carbon dioxide Unclear L-tyrosine [1]
MR005864 L-tyrosine p-hydroxyphenylacetate Unclear L-tyrosine [1]
MR005863 L-tyrosine p-hydroxyphenylpyruvate Unclear L-tyrosine [1]
MR005860 L-tyrosine Tyramine Unclear L-tyrosine [2], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009123 ABBV-951 Levodopa Unclear - Unclear ABBV-951 [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003504 DOPA 3,4-dihydroxyphenylpropionic acid(DPPA) Unclear L-phenylalanine [4]
MR003508 DOPA DOPP Unclear L-phenylalanine [4]
References
1 Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver
2 Tyrosine decarboxylase from Lactobacillus brevis: soluble expression and characterization. Protein Expr Purif. 2014 Feb;94:33-9.
3 Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease
4 Catabolism of L-phenylalanine and L-tyrosine by Rhodobacter sphaeroides OU5 occurs through 3,4-dihydroxyphenylalanine Res Microbiol. 2007 Jul-Aug;158(6):506-11. doi: 10.1016/j.resmic.2007.04.008.

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