Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003687)
Formula Reactant KW-5338 Product KW-5338 Metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003686 KW-5338 5-hydroxydomperidone Unclear KW-5338 [1]
MR003691 KW-5338 KW-5338 Metabolite M2 Oxidation - Hydrolyzationn KW-5338 [2]
MR003688 KW-5338 KW-5338 Metabolite M3 Oxidation - Hydrolyzationn KW-5338 [2]
MR003689 KW-5338 KW-5338 Metabolite M4 Oxidation - Hydrolyzationn KW-5338 [2]
MR003690 KW-5338 KW-5338 Metabolite M5 Oxidation - Hydrolyzationn KW-5338 [2]
References
1 Characterization of CYP3A isozymes involved in the metabolism of domperidone: role of cytochrome b5 and inhibition by ketoconazole. Drug Metab Lett. 2010 Apr;4(2):95-103.
2 Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone. Xenobiotica. 2004 Nov-Dec;34(11-12):1013-23.

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