Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003886)
Formula
SVG example
Reactant DB-053072 Product Acetyl-coA
Reactant Info Product Info
Metabolic Enzyme Pyruvate dehydrogenase protein X component (PDHX) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003888 DB-053072 Carbon dioxide Unclear DB-053072 [1]
MR003890 DB-053072 Formate Unclear DB-053072 [1]
MR003878 DB-053072 Oxaloacetate Unclear DB-053072 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012773 Azelaic Acid Acetyl CoA Oxidation - Oxidation Azelaic Acid [3]
MR004455 Oxoglutarate Acetyl-CoA Unclear Oxoglutarate [4]
MR000045 Acetic acid Acetyl-CoA Unclear Acetaldehyde [5], [6], [7]
MR006974 Acetoacetyl-CoA Acetyl coenzyme A Unclear HSDB-41 [8]
MR004899 Undecanoate Acetyl Coenzyme A Oxidation - Oxidationn Testosterone undecanoate [9]
MR005600 Beta-Ketophenylbutyryl-CoA Acetyl-CoA Unclear Sodium phenylbutyrate [10]
MR013771 Beta-Ketophenylbutyryl-CoA Acetyl-CoA Unclear - Unclear phenylbutyrate [11]
MR004003 2-amino-3-muconicsemi-aldehyde Acetyl-CoA Unclear TRP-01 [12]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004900 Acetyl Coenzyme A Propionyl Coenzyme A Oxidation - Oxidationn Testosterone undecanoate [9]
References
1 Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-(13)C]Pyruvate
2 Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function
3 Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders
4 The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite
5 [The metabolism of alcohol] Rev Med Liege. 2019 May;74(5-6):265-267.
6 Characterization of Thermotoga neapolitana Alcohol Dehydrogenases in the Ethanol Fermentation Pathway. Biology (Basel). 2022 Sep 5;11(9):1318. doi: 10.3390/biology11091318.
7 ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension. Circulation. 2021 May 25;143(21):2074-2090. doi: 10.1161/CIRCULATIONAHA.120.048845.
8 The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14.
9 DrugBank(Pharmacology-Metabolism):Testosterone undecanoate
10 Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate
11 Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
12 Neurotoxicity of tryptophan metabolites

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