Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004455)
Formula
SVG example
Reactant Oxoglutarate Product Acetyl-CoA
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004452 Oxoglutarate Glutamate Unclear Oxoglutarate [1]
MR004456 Oxoglutarate Oxoglutarate Metabolite C2 Oxidation - Oxidationn Oxoglutarate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012773 Azelaic Acid Acetyl CoA Oxidation - Oxidation Azelaic Acid [3]
MR003886 DB-053072 Acetyl-coA Unclear DB-053072 [4]
MR000045 Acetic acid Acetyl-CoA Unclear Acetaldehyde [5], [6], [7]
MR006974 Acetoacetyl-CoA Acetyl coenzyme A Unclear HSDB-41 [8]
MR004899 Undecanoate Acetyl Coenzyme A Oxidation - Oxidationn Testosterone undecanoate [9]
MR005600 Beta-Ketophenylbutyryl-CoA Acetyl-CoA Unclear Sodium phenylbutyrate [10]
MR013771 Beta-Ketophenylbutyryl-CoA Acetyl-CoA Unclear - Unclear phenylbutyrate [11]
MR004003 2-amino-3-muconicsemi-aldehyde Acetyl-CoA Unclear TRP-01 [12]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004900 Acetyl Coenzyme A Propionyl Coenzyme A Oxidation - Oxidationn Testosterone undecanoate [9]
References
1 The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite
2 The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species
3 Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders
4 Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-(13)C]Pyruvate
5 [The metabolism of alcohol] Rev Med Liege. 2019 May;74(5-6):265-267.
6 Characterization of Thermotoga neapolitana Alcohol Dehydrogenases in the Ethanol Fermentation Pathway. Biology (Basel). 2022 Sep 5;11(9):1318. doi: 10.3390/biology11091318.
7 ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension. Circulation. 2021 May 25;143(21):2074-2090. doi: 10.1161/CIRCULATIONAHA.120.048845.
8 The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14.
9 DrugBank(Pharmacology-Metabolism):Testosterone undecanoate
10 Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate
11 Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
12 Neurotoxicity of tryptophan metabolites

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