Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006974)
Formula
SVG example
Reactant Acetoacetyl-CoA Product Acetyl coenzyme A
Reactant Info Product Info
Metabolic Enzyme Unclear metabolic mechanism (fadA) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002976 Acetyl-CoA Acetoacetyl-CoA Oxidation - Beta Oxidation Acetyl-CoA [1], [2]
MR006973 Acetoacetate Acetoacetyl-CoA Unclear HSDB-41 [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002977 Acetoacetyl-CoA HMG-CoA Unclear - Unclear Acetyl-CoA [4], [2]
MR002982 Acetoacetyl-CoA Malonyl-CoA Unclear - Unclear Acetyl-CoA [4], [5], [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012773 Azelaic Acid Acetyl CoA Oxidation - Oxidation Azelaic Acid [7]
MR003886 DB-053072 Acetyl-coA Unclear DB-053072 [8]
MR004455 Oxoglutarate Acetyl-CoA Unclear Oxoglutarate [9]
MR000045 Acetic acid Acetyl-CoA Unclear Acetaldehyde [10], [11], [12]
MR004899 Undecanoate Acetyl Coenzyme A Oxidation - Oxidationn Testosterone undecanoate [13]
MR005600 Beta-Ketophenylbutyryl-CoA Acetyl-CoA Unclear Sodium phenylbutyrate [14]
MR013771 Beta-Ketophenylbutyryl-CoA Acetyl-CoA Unclear - Unclear phenylbutyrate [15]
MR004003 2-amino-3-muconicsemi-aldehyde Acetyl-CoA Unclear TRP-01 [16]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004900 Acetyl Coenzyme A Propionyl Coenzyme A Oxidation - Oxidationn Testosterone undecanoate [13]
References
1 U. S. FDA Label -Acetyl-CoA
2 Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders. Front Endocrinol (Lausanne). 2022 Oct 20;13:972890. doi: 10.3389/fendo.2022.972890.
3 The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14.
4 Compartmentalised acyl-CoA metabolism and roles in chromatin regulation Mol Metab. 2020 Aug;38:100941. doi: 10.1016/j.molmet.2020.01.005.
5 High throughput (13)C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux. Microb Cell Fact. 2023 Jun 29;22(1):117. doi: 10.1186/s12934-023-02123-0.
6 Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program. Cell Rep. 2023 May 30;42(5):112488. doi: 10.1016/j.celrep.2023.112488.
7 Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders
8 Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-(13)C]Pyruvate
9 The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite
10 [The metabolism of alcohol] Rev Med Liege. 2019 May;74(5-6):265-267.
11 Characterization of Thermotoga neapolitana Alcohol Dehydrogenases in the Ethanol Fermentation Pathway. Biology (Basel). 2022 Sep 5;11(9):1318. doi: 10.3390/biology11091318.
12 ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension. Circulation. 2021 May 25;143(21):2074-2090. doi: 10.1161/CIRCULATIONAHA.120.048845.
13 DrugBank(Pharmacology-Metabolism):Testosterone undecanoate
14 Evidence for involvement of medium chain acyl-CoA dehydrogenase in the metabolism of phenylbutyrate
15 Phase 2 comparison of a novel ammonia scavenging agent with sodium phenylbutyrate in patients with urea cycle disorders: safety, pharmacokinetics and ammonia control
16 Neurotoxicity of tryptophan metabolites

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