Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004345)
Formula
SVG example
Reactant Nicotinamide (NAM) Product N-methylnicotinamide
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010729 Nicorandil Nicotinamide Unclear - Unclear Nicorandil [1]
MR004344 Nicotinate-MN Nicotinamide (NAM) Unclear Nicotinate-MN [2]
MR003985 SRT-647 Nicotinamide (NAM) Hydrolysis - Hydrolysis SRT-647 [3], [4]
MR004389 NAD+ Nicotinamide (NAM) Unclear NMN zwitterion [5]
MR005791 NAD+ Nicotinamide (NAM) Unclear Deamido-NAD [6]
MR012863 NAD+ Nicotinamide (NAM) Unclear D-ribosylnicotinate [7]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004348 Nicotinamide (NAM) Nicotinamide adenine dinucleotide Unclear Nicotinate-MN [2]
MR003986 Nicotinamide (NAM) Nicotinic acid Unclear SRT-647 [4]
MR005792 Nicotinamide (NAM) NA Unclear Deamido-NAD [6]
MR005795 Nicotinamide (NAM) Nicotinamide mononucleotide(NMN) Unclear Deamido-NAD [6]
MR012865 Nicotinamide (NAM) Nicotinic acid Unclear D-ribosylnicotinate [7]
MR012864 Nicotinamide (NAM) NMN Unclear D-ribosylnicotinate [7]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010727 Nicorandil Nicorandil Metabolite M3(N-methyl nicotinamide) Unclear - Unclear Nicorandil [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004346 N-methylnicotinamide N-methyl-2-pyridone-5-carboxamide Unclear Nicotinate-MN [2]
References
1 Pharmacokinetics of nicorandil
2 Effects of formulation design on niacin therapeutics: mechanism of action, metabolism, and drug delivery
3 Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
4 BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
5 #NAME?
6 Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. J Biol Chem. 2003 Mar 28;278(13):10914-21.
7 Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

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