General Information of This Metabolic Reaction (MR) (ID: MR012863)
Formula
SIR2 ...
SVG example
Reactant NAD+ Product Nicotinamide (NAM)
Reactant Info Product Info
Metabolic Enzyme NAD-dependent histone deacetylase SIR2 (SIR2) DME Info
NAD-dependent protein deacetylase HST1 (HST1) DME Info
NAD-dependent protein deacetylase HST2 (HST2) DME Info
NAD-dependent protein deacetylase HST3 (HST3) DME Info
NAD-dependent protein deacetylase HST4 (HST4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005790 Deamido-NAD NAD+ Unclear Deamido-NAD [1]
MR004388 NMN zwitterion NAD+ Unclear NMN zwitterion [2]
MR004348 Nicotinamide (NAM) Nicotinamide adenine dinucleotide Unclear Nicotinate-MN [3]
MR012862 NaAD+ NAD+ Unclear D-ribosylnicotinate [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010729 Nicorandil Nicotinamide Unclear - Unclear Nicorandil [5]
MR004344 Nicotinate-MN Nicotinamide (NAM) Unclear Nicotinate-MN [3]
MR003985 SRT-647 Nicotinamide (NAM) Hydrolysis - Hydrolysis SRT-647 [6], [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004345 Nicotinamide (NAM) N-methylnicotinamide Unclear Nicotinate-MN [3]
MR004348 Nicotinamide (NAM) Nicotinamide adenine dinucleotide Unclear Nicotinate-MN [3]
MR003986 Nicotinamide (NAM) Nicotinic acid Unclear SRT-647 [7]
MR005792 Nicotinamide (NAM) NA Unclear Deamido-NAD [1]
MR005795 Nicotinamide (NAM) Nicotinamide mononucleotide(NMN) Unclear Deamido-NAD [1]
MR012865 Nicotinamide (NAM) Nicotinic acid Unclear D-ribosylnicotinate [4]
MR012864 Nicotinamide (NAM) NMN Unclear D-ribosylnicotinate [4]
⏷ Show the Full List of MR
References
1 Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. J Biol Chem. 2003 Mar 28;278(13):10914-21.
2 #NAME?
3 Effects of formulation design on niacin therapeutics: mechanism of action, metabolism, and drug delivery
4 Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism
5 Pharmacokinetics of nicorandil
6 Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
7 BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

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