General Information of This Metabolic Reaction (MR) (ID: MR012865)
Formula
cyp51A ...
SVG example
Reactant Nicotinamide (NAM) Product Nicotinic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 monooxygenase 51A (cyp51A) DME Info
Solute carrier family 25 member 33 (SLC25A33) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010729 Nicorandil Nicotinamide Unclear - Unclear Nicorandil [1]
MR004344 Nicotinate-MN Nicotinamide (NAM) Unclear Nicotinate-MN [2]
MR003985 SRT-647 Nicotinamide (NAM) Hydrolysis - Hydrolysis SRT-647 [3], [4]
MR004389 NAD+ Nicotinamide (NAM) Unclear NMN zwitterion [5]
MR005791 NAD+ Nicotinamide (NAM) Unclear Deamido-NAD [6]
MR012863 NAD+ Nicotinamide (NAM) Unclear D-ribosylnicotinate [7]
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Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004345 Nicotinamide (NAM) N-methylnicotinamide Unclear Nicotinate-MN [2]
MR004348 Nicotinamide (NAM) Nicotinamide adenine dinucleotide Unclear Nicotinate-MN [2]
MR005795 Nicotinamide (NAM) Nicotinamide mononucleotide(NMN) Unclear Deamido-NAD [6]
MR012864 Nicotinamide (NAM) NMN Unclear D-ribosylnicotinate [7]
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Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012859 D-ribosylnicotinate Nicotinic acid Unclear D-ribosylnicotinate [7]
MR010728 Nicorandil Nicotinic acid Unclear - Unclear Nicorandil [1]
MR004350 Nicotinyl alcohol Nicotinic acid Unclear Nicotinyl alcohol [8]
MR012775 Trientine NA Conjugation - Acetylation Trientine [9], [10]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012860 Nicotinic acid NaMN Unclear D-ribosylnicotinate [7]
MR005793 NA NaMN Unclear Deamido-NAD [6]
References
1 Pharmacokinetics of nicorandil
2 Effects of formulation design on niacin therapeutics: mechanism of action, metabolism, and drug delivery
3 Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
4 BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities
5 #NAME?
6 Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. J Biol Chem. 2003 Mar 28;278(13):10914-21.
7 Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism
8 Antihyperlipidemic properties of beta-pyridylcarbinol. A review of preclinical studies
9 Triethylenetetramine pharmacology and its clinical applications
10 Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects

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