Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004737)
Formula
CYP1A2 ...
SVG example
Hydrolyzationn
Reactant Mexiletine hydrochloride Product p-hydroxymexiletine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004735 Mexiletine hydrochloride 2-hydroxymexiletine Oxidation - 2-hydroxylation Mexiletine hydrochloride [1]
MR004739 Mexiletine hydrochloride M-hydroxy ME Unclear Mexiletine hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004738 p-hydroxymexiletine Deamino pHME Unclear Mexiletine hydrochloride [3]
References
1 Involvement of CYP1A2 in mexiletine metabolism. Br J Clin Pharmacol. 1998 Jul;46(1):55-62.
2 [Thyroid neoplasms and HL-A system]
3 Inhibition kinetics of theophylline metabolism by mexiletine and its metabolites

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