Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004756)
Formula
SVG example
O-demethylation
Reactant Midostaurin Product CGP 62221
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004755 Midostaurin CGP 52421 Oxidation - 7-hydroxylation Midostaurin [1], [2]
MR004753 Midostaurin Midostaurin Metabolite P6 Unclear Midostaurin [3]
References
1 Midostaurin: an emerging treatment for acute myeloid leukemia patients
2 Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth
3 Midostaurin, a novel protein kinase inhibitor for the treatment of acute myelogenous leukemia: insights from human absorption, metabolism, and excretion studies of a BDDCS II drug. Drug Metab Dispos. 2017 May;45(5):540-555.

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