General Information of This Metabolic Reaction (MR) (ID: MR004753)
Formula
SVG example
Reactant Midostaurin Product Midostaurin Metabolite P6
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004755 Midostaurin CGP 52421 Oxidation - 7-hydroxylation Midostaurin [1], [2]
MR004756 Midostaurin CGP 62221 Oxidation - O-demethylation Midostaurin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005729 Benzyl alcohol Benzoic Acid Oxidation - Oxidationn Benzyl alcohol [3], [4]
MR007541 Benzylamine Benzylamine M16 Unclear Benzylamine [5]
MR004299 Naphthoquinone Benzoic acid Unclear Naphthoquinone [6]
MR000218 Phenylacetone Benzoic acid Oxidation - Oxidation Amphetamine [7]
MR012043 Triamide Benzoic acid Unclear - Unclear Farglitazar [8]
MR003835 3-Phenylpropionic acid Benzoic acid Unclear BE-14348A [9]
MR012039 Farglitazar Metabolites M3 Benzoic acid Hydrolysis - Hydrolysis Farglitazar [8]
MR009986 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Metamfetamine [10]
MR010002 Metamfetamine Metabolite M5 Benzoic acid Unclear - Unclear Methamphetamine hydrochloride [10]
MR012038 Benzamide Benzoic acid Hydrolysis - Hydrolysis Farglitazar [8]
MR006884 Phenylacetone Benzoic Acid Unclear Lisdexamfetamine [11]
MR009198 3-(phenyl)acetic acid Benzoic acid Oxidation - Oxidation 3,4-Dihydroxycinnamic Acid [12]
MR005288 Cinnamic acid Metabolite Benzoic acid Unclear Cinnamic acid [13]
MR004493 3-Hydroxybenzoic acid Benzoic acid Unclear VS-12343 [14]
MR004491 Phenylacetic acid Benzoic acid Unclear VS-12343 [14]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007547 Benzylamine M16 Benzylamine M1 Unclear Benzylamine [5]
MR007542 Benzylamine M16 Benzylamine M12 Unclear Benzylamine [5]
MR004754 Midostaurin Metabolite P6 Midostaurin Metabolite P6B Unclear Midostaurin [15]
References
1 Midostaurin: an emerging treatment for acute myeloid leukemia patients
2 Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth
3 Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toxicol Appl Pharmacol. 1995 Aug;133(2):295-304.
4 Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
5 Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates
6 Identification of naphthalene metabolism by white rot fungus Pleurotus eryngii
7 DrugBank(Pharmacology-Metabolism)Amphetamine
8 The Degradation Chemistry of Farglitazar and Elucidation of the Oxidative Degradation Mechanisms
9 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
10 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat
11 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
12 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota
13 Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose
14 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
15 Midostaurin, a novel protein kinase inhibitor for the treatment of acute myelogenous leukemia: insights from human absorption, metabolism, and excretion studies of a BDDCS II drug. Drug Metab Dispos. 2017 May;45(5):540-555.

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