Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004882)
Formula Reactant Nateglinide Product Nateglinide glucuronide and isomers (M4/M5/M6)
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2A1 (UGT2A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004883 Nateglinide 2-{[4-(1-hydroxypropan-2-yl)cyclohexyl]formamido}-3-phenylpropanoic acid Oxidation - Aliphatic hydroxylation Nateglinide [1]
MR004884 Nateglinide 2-{[4-(2-hydroxypropan-2-yl)cyclohexyl]formamido}-3-phenylpropanoic acid Oxidation - Aliphatic hydroxylation Nateglinide [1]
MR004878 Nateglinide Nateglinide metabolite M1 Oxidation - Hydrolyzationn Nateglinide [1]
MR004876 Nateglinide Nateglinide metabolite M2/M3 Oxidation - Hydrolyzationn Nateglinide [1], [2]
MR004880 Nateglinide Nateglinide metabolite M7 Oxidation - Oxidationn Nateglinide [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacokinetics of nateglinide enantiomers and their metabolites in Goto-Kakizaki rats, a model for type 2 diabetes mellitus

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