Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004878)
Formula
CYP2C9 ...
SVG example
Hydrolyzationn
Reactant Nateglinide Product Nateglinide metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004883 Nateglinide 2-{[4-(1-hydroxypropan-2-yl)cyclohexyl]formamido}-3-phenylpropanoic acid Oxidation - Aliphatic hydroxylation Nateglinide [1]
MR004884 Nateglinide 2-{[4-(2-hydroxypropan-2-yl)cyclohexyl]formamido}-3-phenylpropanoic acid Oxidation - Aliphatic hydroxylation Nateglinide [1]
MR004882 Nateglinide Nateglinide glucuronide and isomers (M4/M5/M6) Conjugation - Glucuronidation Nateglinide [1]
MR004876 Nateglinide Nateglinide metabolite M2/M3 Oxidation - Hydrolyzationn Nateglinide [1], [2]
MR004880 Nateglinide Nateglinide metabolite M7 Oxidation - Oxidationn Nateglinide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004879 Nateglinide metabolite M1 Nateglinide metabolite M11/M12 Oxidation - Hydrolyzationn Nateglinide [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacokinetics of nateglinide enantiomers and their metabolites in Goto-Kakizaki rats, a model for type 2 diabetes mellitus

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