Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004883)
Formula Reactant Nateglinide Product 2-{[4-(1-hydroxypropan-2-yl)cyclohexyl]formamido}-3-phenylpropanoic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004884 Nateglinide 2-{[4-(2-hydroxypropan-2-yl)cyclohexyl]formamido}-3-phenylpropanoic acid Oxidation - Aliphatic hydroxylation Nateglinide [1]
MR004882 Nateglinide Nateglinide glucuronide and isomers (M4/M5/M6) Conjugation - Glucuronidation Nateglinide [1]
MR004878 Nateglinide Nateglinide metabolite M1 Oxidation - Hydrolyzationn Nateglinide [1]
MR004876 Nateglinide Nateglinide metabolite M2/M3 Oxidation - Hydrolyzationn Nateglinide [1], [2]
MR004880 Nateglinide Nateglinide metabolite M7 Oxidation - Oxidationn Nateglinide [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacokinetics of nateglinide enantiomers and their metabolites in Goto-Kakizaki rats, a model for type 2 diabetes mellitus

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