Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004892)
Formula Reactant Nefazodone Product 3-[3-ethyl-5-oxo-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]propanal
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004885 Nefazodone Hydroxynefazodone Oxidation - Hydrolyzationn Nefazodone [1]
MR004891 Nefazodone M-Chlorophenylpiperazine Unclear Nefazodone [2]
MR004888 Nefazodone Nefazodone Metabolite E Unclear Nefazodone [2]
References
1 DrugBank(Pharmacology-Metabolism):Nefazodone
2 Clinical pharmacokinetics of nefazodone. Clin Pharmacokinet. 1997 Oct;33(4):260-75.

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