Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004891)
Formula
SVG example
Reactant Nefazodone Product M-Chlorophenylpiperazine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004892 Nefazodone 3-[3-ethyl-5-oxo-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]propanal Oxidation - N-dealkylation Nefazodone [1]
MR004885 Nefazodone Hydroxynefazodone Oxidation - Hydrolyzationn Nefazodone [1]
MR004888 Nefazodone Nefazodone Metabolite E Unclear Nefazodone [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013453 Etoperidone 1-(3-chlorophenyl) piperazine Unclear Etoperidone [3], [4]
MR002444 Trazodone hydrochloride M-chlorophenylpiperazine Oxidation - N-Dealkylation Trazodone hydrochloride [5]
MR004886 Hydroxynefazodone M-Chlorophenylpiperazine Unclear Nefazodone [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013454 1-(3-chlorophenyl) piperazine Etoperidone Metabolite N9 Oxidation - N-dealkylation Etoperidone [3]
MR004887 M-Chlorophenylpiperazine p-hydroxy-mCPP Unclear Nefazodone [2]
References
1 DrugBank(Pharmacology-Metabolism):Nefazodone
2 Clinical pharmacokinetics of nefazodone. Clin Pharmacokinet. 1997 Oct;33(4):260-75.
3 Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man
4 In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica. 2002 Nov;32(11):949-62.
5 Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats Int J Neuropsychopharmacol. 1999 Mar;2(1):17-23. doi: 10.1017/S1461145799001303.

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