Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004925)
Formula
SVG example
Amide Hydrolyation
Reactant Thalidomide Product Alpha-(o-carboxybenzamido)glutarimide
Reactant Info Product Info
Metabolic Enzyme Nonenzymatical (Non-ME) DME Info
Metabolic Type Conjugation - Amide Hydrolyation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004921 Thalidomide 2-phthalimidoglutaramic acid Conjugation - Amide Hydrolyation Thalidomide [1], [2]
MR004943 Thalidomide 4-hydroxythalidomide Oxidation - Hydrolyzationn Thalidomide [3]
MR004914 Thalidomide 4-phthalimidoglutaramic acid Conjugation - Amide Hydrolyation Thalidomide [1], [2]
MR004934 Thalidomide 5-Hydroxythalidomide Oxidation - Aromatic hydroxylation Thalidomide [4], [2]
MR004937 Thalidomide Cis, trans-5'-Hydroxythalidomide Oxidation - Hydrolyzationn Thalidomide [4], [2]
MR004942 Thalidomide N-Hydroxythalidomide Oxidation - Hydrolyzation Thalidomide [3]
MR004939 Thalidomide Thalidomide arene oxide Oxidation - Epoxidation Thalidomide [4], [2]
MR004941 Thalidomide Thalidomide-5-O-glucuronide Oxidation - Hydrolyzationn Thalidomide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004926 Alpha-(o-carboxybenzamido)glutarimide 2-(o-carboxybenzamido)glutaramic acid Conjugation - Amide Hydrolyation Thalidomide [2]
MR004933 Alpha-(o-carboxybenzamido)glutarimide Alpha-aminoglutarimide Conjugation - Amide Hydrolyation Thalidomide [2]
MR004932 Alpha-(o-carboxybenzamido)glutarimide Phthalic Acid Conjugation - Amide Hydrolyation Thalidomide [2]
References
1 Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
2 Thalidomide metabolism and hydrolysis: mechanisms and implications
3 Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients. J Biochem Mol Toxicol. 2000;14(3):140-7.
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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