Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004926)
Formula
SVG example
Amide Hydrolyation
Reactant Alpha-(o-carboxybenzamido)glutarimide Product 2-(o-carboxybenzamido)glutaramic acid
Reactant Info Product Info
Metabolic Enzyme Nonenzymatical (Non-ME) DME Info
Metabolic Type Conjugation - Amide Hydrolyation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004925 Thalidomide Alpha-(o-carboxybenzamido)glutarimide Conjugation - Amide Hydrolyation Thalidomide [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004933 Alpha-(o-carboxybenzamido)glutarimide Alpha-aminoglutarimide Conjugation - Amide Hydrolyation Thalidomide [2]
MR004932 Alpha-(o-carboxybenzamido)glutarimide Phthalic Acid Conjugation - Amide Hydrolyation Thalidomide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004922 2-phthalimidoglutaramic acid 2-(o-carboxybenzamido)glutaramic acid Conjugation - Amide Hydrolyation Thalidomide [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014136 2-(o-carboxybenzamido)glutaramic acid 2-(o-carboxybenzamido)glutaric acid Conjugation - Amide Hydrolyation Thalidomide [1]
MR004930 2-(o-carboxybenzamido)glutaramic acid L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [2]
MR004931 2-(o-carboxybenzamido)glutaramic acid Phthalic Acid Conjugation - Amide Hydrolyation Thalidomide [2]
References
1 Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
2 Thalidomide metabolism and hydrolysis: mechanisms and implications

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