Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004930)
Formula
SVG example
Amide Hydrolyation
Reactant 2-(o-carboxybenzamido)glutaramic acid Product L-Glutamine
Reactant Info Product Info
Metabolic Enzyme Nonenzymatical (Non-ME) DME Info
Metabolic Type Conjugation - Amide Hydrolyation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004922 2-phthalimidoglutaramic acid 2-(o-carboxybenzamido)glutaramic acid Conjugation - Amide Hydrolyation Thalidomide [1]
MR004926 Alpha-(o-carboxybenzamido)glutarimide 2-(o-carboxybenzamido)glutaramic acid Conjugation - Amide Hydrolyation Thalidomide [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014136 2-(o-carboxybenzamido)glutaramic acid 2-(o-carboxybenzamido)glutaric acid Conjugation - Amide Hydrolyation Thalidomide [1]
MR004931 2-(o-carboxybenzamido)glutaramic acid Phthalic Acid Conjugation - Amide Hydrolyation Thalidomide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000202 Ammonia Glutamine Conjugation - Condensation Ammonia [3]
MR003638 Glutamic acid Glutamine Unclear Glutamic acid [4]
MR004453 Glutamate Glutamine Unclear Oxoglutarate [5]
MR000199 L-glutamate Glutamine Unclear Ammonia [6]
MR014138 2-(o-carboxybenzamido)glutaric acid L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [2]
MR012744 L-Glutamate L-Glutamine Unclear - Unclear Arginine [7]
MR014139 L-Glutamine L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [2]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014139 L-Glutamine L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [2]
References
1 Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
2 Thalidomide metabolism and hydrolysis: mechanisms and implications
3 Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases J Hepatol. 2016 Apr;64(4):860-71. doi: 10.1016/j.jhep.2015.11.018.
4 Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
5 The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite
6 Metabolism of glutamate and ammonia in astrocyte: an immunocytochemical study Brain Res. 1988 Aug 2;457(1):160-4. doi: 10.1016/0006-8993(88)90069-8.
7 Arginine Metabolism Revisited

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