Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004948)
Formula
SVG example
Reactant Theophylline Product Caffeine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004947 Theophylline 1,3-dimethyluric acid Oxidation - 8-hydroxylation Theophylline [1]
MR004944 Theophylline 1-Methylxanthine Oxidation - 3-N-demethylation Theophylline [1]
MR004946 Theophylline 3-methylxanthine Oxidation - 1-N-demethylation Theophylline [1]
MR000547 Theophylline 1-Methylxanthine Oxidation - 3-N-Demethylation Caffeine [2], [3]
References
1 Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7.
2 In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios Biomed Chromatogr. 2007 Feb;21(2):190-200. doi: 10.1002/bmc.736.
3 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.

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