Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004947)
Formula
SVG example
8-hydroxylation
Reactant Theophylline Product 1,3-dimethyluric acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - 8-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004944 Theophylline 1-Methylxanthine Oxidation - 3-N-demethylation Theophylline [1]
MR004946 Theophylline 3-methylxanthine Oxidation - 1-N-demethylation Theophylline [1]
MR004948 Theophylline Caffeine Unclear Theophylline [2]
MR000547 Theophylline 1-Methylxanthine Oxidation - 3-N-Demethylation Caffeine [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001874 Oxtriphylline 1,3-Dimethyluric acid Unclear Oxtriphylline [5]
References
1 Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7.
2 Metabolism of theophylline to caffeine in human fetal liver
3 In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios Biomed Chromatogr. 2007 Feb;21(2):190-200. doi: 10.1002/bmc.736.
4 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.
5 Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma Clin Pharmacol Ther. 2003 May;73(5):468-74. doi: 10.1016/s0009-9236(03)00013-4.

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