Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005003)
Formula Reactant Tipranavir Product Tipranavir Metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Monohydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005002 Tipranavir Tipranavir Metabolite Oxidation - Monohydroxylation Tipranavir [1]
MR005004 Tipranavir Tipranavir Metabolite Oxidation - Monohydroxylation Tipranavir [1]
MR005005 Tipranavir Tipranavir Metabolite Oxidation - Depropylation Tipranavir [1]
MR005006 Tipranavir Tipranavir Metabolite Oxidation - Dehydrogenation Tipranavir [1]
MR005007 Tipranavir Tipranavir Metabolite Oxidation - Dehydrogenation Tipranavir [1]
MR005008 Tipranavir Tipranavir Metabolite Oxidation - Dehydrogenation Tipranavir [1]
MR005009 Tipranavir Tipranavir Metabolite Oxidation - Dihydroxylation Tipranavir [1]
References
1 Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May;38(5):871-8.

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