Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005013)
Formula
CYP2C19 ...
SVG example
O-dealkylation
Reactant Norfluoxetine Product 4-Trifluoromethylphenol
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005012 Fluoxetine hydrochloride Norfluoxetine Oxidation - N-demethylation Fluoxetine hydrochloride [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005015 Norfluoxetine Norfluoxetine alcohol Oxidation - Oxidationn deamination Fluoxetine hydrochloride [2]
MR005017 Norfluoxetine Norfluoxetine glucuronide Conjugation - Glucuronidation Fluoxetine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005018 Fluoxetine hydrochloride 4-Trifluoromethylphenol Oxidation - O-dealkylation Fluoxetine hydrochloride [5], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005014 4-Trifluoromethylphenol Hippuric acid Oxidation - O-dealkylation Fluoxetine hydrochloride [6]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91.
4 Simultaneous identification and quantitation of fluoxetine and its metabolite, norfluoxetine, in biological samples by GC-MS
5 O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes. J Pharmacol Exp Ther. 2002 Jan;300(1):105-11.
6 DrugBank(Pharmacology-Metabolism):Fluoxetine hydrochloride

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