General Information of This Metabolic Reaction (MR) (ID: MR005014)
Formula
CYP2C19 ...
SVG example
O-dealkylation
Reactant 4-Trifluoromethylphenol Product Hippuric acid
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005018 Fluoxetine hydrochloride 4-Trifluoromethylphenol Oxidation - O-dealkylation Fluoxetine hydrochloride [1], [2]
MR005013 Norfluoxetine 4-Trifluoromethylphenol Oxidation - O-dealkylation Fluoxetine hydrochloride [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010230 Isocarboxazid Hippuric acid Unclear - Unclear Isocarboxazid [4]
MR007547 Benzylamine M16 Benzylamine M1 Unclear Benzylamine [5]
MR004754 Midostaurin Metabolite P6 Midostaurin Metabolite P6B Unclear Midostaurin [6]
MR000219 Benzoic acid Hippuric acid Conjugation - Glycine Conjugation Amphetamine [7]
MR006962 3-(Phenyl)propionic acid Hippuric acid Unclear CCG-208408 [8]
MR003837 Benzoic acid Hippuric acid Unclear BE-14348A [9]
MR006885 Phenylacetone Hippuric acid Unclear Lisdexamfetamine [10]
MR005290 Cinnamic acid Metabolite Hippuric acid Unclear Cinnamic acid [11]
MR009199 Benzoic acid Hippuric acid Conjugation - Glycination 3,4-Dihydroxycinnamic Acid [12]
MR013577 4'-hydroxybenzoic acid Hippuric acid Unclear Epigallocatechin gallate [13]
⏷ Show the Full List of MR
References
1 O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes. J Pharmacol Exp Ther. 2002 Jan;300(1):105-11.
2 Simultaneous identification and quantitation of fluoxetine and its metabolite, norfluoxetine, in biological samples by GC-MS
3 DrugBank(Pharmacology-Metabolism):Fluoxetine hydrochloride
4 DrugBank(Pharmacology-Metabolism):Isocarboxazid
5 Bioactivation of benzylamine to reactive intermediates in rodents: formation of glutathione, glutamate, and peptide conjugates
6 Midostaurin, a novel protein kinase inhibitor for the treatment of acute myelogenous leukemia: insights from human absorption, metabolism, and excretion studies of a BDDCS II drug. Drug Metab Dispos. 2017 May;45(5):540-555.
7 DrugBank(Pharmacology-Metabolism)Amphetamine
8 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
9 High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
10 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
11 Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose
12 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota
13 Absorption, metabolism, bioactivity, and biotransformation of epigallocatechin gallate

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